The Long and Short Non-coding RNAs in Cancer Biology free download PDF, EPUB, Kindle

• Date: 12 Jul 2016
• Publisher: Springer Verlag, Singapore
• Original Languages: English
• Book Format: Hardback::458 pages, ePub, Audiobook
• ISBN10: 9811014965
• ISBN13: 9789811014963
• Dimension: 155x 235x 25.4mm::8,218g

Download Link: The Long and Short Non-coding RNAs in Cancer Biology

The Long and Short Non-coding RNAs in Cancer Biology free download PDF, EPUB, Kindle. The discovery of numerous long non-coding RNA (lncRNA) transcripts novel research directions have emerged in cancer-related lncRNA field. Brief functional description about associations between lncRNA and cancer More recently, a focus on lncRNAs and other noncoding RNAs has emerged including We invite all attendees to submit a full-length research article from their In short: I hope you will also find a little time for leisure and enjoyment during Long non-coding RNAs (lncRNAs) are important regulators of gene expression that influence almost every step in the life cycle of genes, from transcription to mRNA splicing, RNA decay, and translation. Besides their participation to normal physiology, lncRNA expression and function have been already associated to cancer development and However, in which way the emerging abundance of different non-coding RNAs supports tumour progression is poorly understood. Here, we review new lines of evidence linking long and short types of non-coding RNAs to signalling pathways activated in the course of cancer progression growth factors and the tumour micro-environment. Non-coding RNAs (ncRNAs) participate in complex networks of interactions with other nucleic acids and proteins that often have wide-reaching effects on cell biology Abstract: Long non-coding RNAs (lncRNAs) refer to a group of RNAs that are usually In this review, we describe the oncogenic roles of HOTAIR long-non coding HOTAIR and HER2 is worth to research in other types of cancer cells. Is associated with short disease-free survival in human non-small cell lung cancer. The Long and Short Non-coding RNAs in Cancer Biology 1st ed. 2016 Edition, Erwei Song PDF | Title: The Long and Short Non-coding RNAs in Cancer Biology (Advances in Experimental Medicine and Biology)ISBN-13: 978-9811014963ISBN-10: 9811014965Author: In particular, long noncoding RNAs (ncRNAs that are >200 nt long) biological processes and human diseases including cancer. MALAT1 undergoes posttranscriptional processing to produce a short RNA (cytoplasmic Nevertheless, it is evident that cancer-associated lincRNAs may provide new approaches to the diagnosis and treatment of cancer. Long intronic non-coding RNAs. The biogenesis of long intronic ncRNAs is poorly understood at this time. Nevertheless, there are some indirect evidences that indicate an involvement of RNA polymerase II (RNAPII). Despite an inability to encode proteins, small noncoding RNAs in normal and cancer biology relies on numerous in silico workflows and tools single-stranded sncRNAs, derived from endogenous short hairpin transcripts, 18 25, [17] (i) Primary processing pathway: cleavage of long piRNA precursors, Non-Coding RNA (ISSN 2311-553X) is an international peer-reviewed open access journal on non-coding RNA research dealing with elucidating the structure, function and biology of regulatory non-coding RNAs. Non-Coding Keystone Symposia on Molecular and Cellular Biology is a nonprofit organization headquartered in pathways controlled miRNAs and long noncoding RNAs; Short Talk: miRNA Regulation of Myocyte Proliferation and the Hippo. The DNA sequence from which a functional non-coding RNA is transcribed is often called an RNA gene. Abundant and functionally important types of non-coding RNAs include transfer RNAs (tRNAs) and ribosomal RNAs (rRNAs), as well as small RNAs such as microRNAs, siRNAs, piRNAs, snoRNAs, snRNAs, exRNAs, scaRNAs and the long Long non-coding RNAs (long ncRNAs, lncRNA) are a type of RNA, defined as being transcripts with lengths exceeding 200 nucleotides that are not translated into protein. This somewhat arbitrary limit distinguishes long ncRNAs from small non-coding RNAs such as microRNAs (miRNAs), small interfering RNAs (siRNAs), Piwi-interacting RNAs Non-coding RNAs: Crossing the Aisle from Cancer to In this review, we highlight recent findings regarding the roles of lncRNAs in cancer biology. Those lncRNAs with a short half-life include known regulatory ncRNAs, Long non-coding RNAs (lncRNAs) represent a major part of the as important players in cancer research [19], particularly as biomarkers Aberrant expression of long non coding RNAs (lncRNAs) has been associated with a variety of malignancies including colon cancer. In this study, we aimed to characterize the biological mechanisms of focally amplified lncRNA on chromosome 1 (FAL1) in colon cancers. Recently, mounting evidence indicates that long noncoding RNAs with CT expression pattern could play a pivotal role in cancer biology. Abstract. Thousands of long noncoding RNAs (lncRNAs) have been discovered in recent years. The functions of lncRNAs range broadly from regulating chromatin structure and gene expression in the nucleus to controlling messenger RNA (mRNA) processing, mRNA posttranscriptional regulation, cellular signaling, and protein activity in the Review Long non-coding RNA protocol, troubleshooting and other Cell Biology: Mechanistic insights are emerging into how long non-coding RNAs I have Digital gene expression data which including exact position of lncRNA from RNA Among these noncoding transcripts, many are long non-coding RNAs in biological processes, cellular components and molecular functions, Gene The lower the p-value, the more significant the GO Term (p-value< = 0.05 Both microRNAs and long non coding RNAs are involved in several fundamental biologic processes, and their deregulation may lead in oncogenesis. Interacting with the Polycomb repressive complex 2 subunit EZH2, they could affect the expression of protein coding genes and form feedback networks and autoregulatory loops. Long non-coding RNAs (lncRNAs) are a large and diverse class of transcribed RNA molecules with a length of more than 200 nucleotides that do not encode proteins (or lack > 100 amino acid open reading frame). LncRNAs are thought to encompass nearly 30,000 different transcripts in humans, hence lncRNA transcripts account for the major part of the Genome-wide cancer mutation analyses are revealing an extensive landscape of functional mutations within the noncoding genome, with profound effects on the expression of long noncoding RNAs (lncRNAs). While the exquisite regulation of lncRNA transcription can provide signals of malignant transformation, we now understand This book may serve as a comprehensive resource for researchers, graduate students and oncologists in ncRNA and cancer research and help drug development identifying ncRNA targets. Number of Illustrations and Tables. 21 b/w illustrations. Topics. Cancer Research. Cell Biology. Download The Long and Short Non-coding RNAs in Cancer Biology The Long and Short Non-coding RNAs in Cancer Biology (1st ed. 2016) (Advances in Experimental Medicine and Biology #927) View larger image. : Erwei Song. Sign Up Now! Already a Member? Log In You must be logged into UK education collection to access this title. Learn about membership options, or view our freely available titles. Long non-coding RNAs (long ncRNAs, lncRNA) are a type of RNA, defined as being transcripts In the broad sense, this mechanism allows the cell to harness RNA-binding The short interspersed nuclear (SINE) Alu elements in humans and recognition that long ncRNAs function in various aspects of cell biology has Of the diverse array of putative molecular and biological functions assigned to long non-coding RNAs Long non-coding RNA cross-talk with epigenetic factors Examples of long non-coding RNAs associated with cancer. Second, and in clear contrast to short ncRNAs, lncRNA expression shows high

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